Every time we mention Cardarine or GW501516, people make a beeline for the hills as if the cancer is going to find them and kill them like Niam Leeson.
That rat study really has people spooked, we tell you.
To be fair, everyone should be petrified to touch anything that could cause cancer.
But we still go out in the sun, we smoke cigarettes like chimneys, we are sleeping with the damn cell phone under our pillows and we are habituated with poking our fingers inside the microwave.
What does that tell you?
How many times have you researched about consuming food heated in a microwave oven and its potential to cause cancer?
For the uninitiated, here are some eye opening facts.
But that’s not our concern.
A PED that has some tremendous applications is being trashed repeatedly because there are conflicting reports about its potential to cause cancer.
How much of this is really true? Let’s separate the chaff from the wheat for once.
What is Cardarine?
GW501516, also called Cardarine or Enduborol is an investigational drug that is often sold and labelled as a Selective Androgenic Receptor Modulator.
In reality, it is a PPARδ receptor agonist, a very novel compound that has the potential to modify gene expression that leads to an increase in energy, endurance and performance.
Think about it like the ability to go on for hour after hour for your cardio. The improved performance leads to better and dramatic results.
The benefits of Cardarine
The benefits of Enduborol don’t end there.
It appears to be a fat burner
Based on anecdotal reviews found on messaging boards all over the internet, it would be fair to say that GW501516 enhances the rate at which your body burns fat. There are users who have dropped their body fat by up to 4-5% with just one month of Cardarine use at doses as low as 10mg/day. That’s as good as what you can get with pharmaceutical grade drugs like Clenbuterol or anabolic steroids like Winstrol. The only difference is that Cardarine does not cause jitters or make your heart race like an engine on nitrous. In fact, most people don’t feel the drug at all throughout the cycle. They just notice that they can perform better along with a visible transformation in their body composition.
It can reduce androgenic dyslipidemia
One of the prerequisites for using PEDs like SARMS or oral steroids, is to have a clean lipid profile. If you have poor HDL levels for example, then using SARMS is not recommended because it will trash it further. Walking around with HDL levels in the single digits isnt really considered healthy in the long run.
GW501516 can increase your levels of HDL, while reducing LDL and triglycerides. That’s a very useful compound right there that can prevent oral AAS from trashing your lipids.
You can even consider adding it to your pre or post SARM cycle stack to get your lipids to normalcy.
By the way, it is effective even at doses as low as 5mg/day.
So, you don’t really need to take 20mg for it to be effective.
Why did GSK and Ligand Pharmaceuticals abandon GW501516?
Now comes the big question. If it is as great as it sounds, then why was it abandoned?
Does it really cause cancer?
There are two to three animal studies that have been instrumental in Cardarine being axed.
- GW501516 was administered to male and female Winsar Rats at different doses for a period of 104 weeks continually. It was noted that it caused cancer to spread aggressively in multiple sites in the body. However, the key takeaway here is that ‘Neoplastic changes were noted at all doses’
- Cardarine was noted to cause colorectal cancer.
Now, there’s no denying that Cardarine did cause the cancer cells in the body of the mice to develop rapidly.
But there are a few things that also must be mentioned.
The doses were given for 104 weeks on the trot.
The average lifespan of a Winstar rat is 2.5 to 3.5 years.
So, Cardarine was administered to the rats for nearly all of its lifespan or at least more than half of its lifespan.
Cancer was formed in the rats even at doses as low as 3mg/day.
What is the human equivalent of those GW501516 doses?
There’s a lot of debate about what the human equivalent of those doses would be.
Some people have posted a lopsided argument that the doses in humans would be 240mg/day.
That’s not correct.
If you convert those doses to humans, it would roughly amount to 40mg/day for a 90kg male or 50mg/day for a 100kg male.
That’s eerily close to what some people use during their cardarine cycles.
BUT, and that’s a big BUT. (no pun intended)
There seems to be some correlation between the cancer cell proliferation and the amount of time that Cardarine is dosed for.
A more recent study conducted in 2018 talks about how it prevented the proliferation of cancer cells, when administered for a much shorter duration.
Other than this, there were four human Phase 1 Clinical trials that were conducted to gauge the effectiveness of the compound in treating dyslipidemia. Very few adverse effects were noted.
Can Cardarine cause cancer?
The bottom line is that we don’t know.
The research is insufficient. But the studies that label it a carcinogen are sketchy to be honest.
No one in a sane state of mind would dose Cardarine for half their lifetime.
Most people would use it for a few weeks at best at doses as low as 20mg/day.
Personally, we don’t think that it causes cancer in humans if used in reasonable doses for short stints.
In fact, the benefits of running it alongside something like RAD140 are too good to ignore.
That’s a body recomposition stack right there. And we have used it on numerous occasions.
But hey, that’s just our personal view.
We have presented all the facts that we have about the compound. This should allow you to make an informed decision.
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